JAK2 Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
JAK2 Peptide Applications :
Blocking Background :
Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. Alternative Name :
JAK 2; JAK-2; JAK2; Janus Activating Kinase 2; Janus Kinase 2; Janus Kinase 2; JTK 10; JTK10; Swiss-Prot :
O60674 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide JAK2. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5769 JAK2 pAb.
JAK2 Peptide Applications :
Blocking Background :
Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. Alternative Name :
JAK 2; JAK-2; JAK2; Janus Activating Kinase 2; Janus Kinase 2; Janus Kinase 2; JTK 10; JTK10; Swiss-Prot :
O60674 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide JAK2. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5769 JAK2 pAb.
Blocking peptide available as BS5769PP